Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain
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منابع مشابه
Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain
Neurofibrillary tangles (NFT) and β-amyloid plaques are the neurological hallmarks of both Alzheimer's disease and an unusual paralytic illness suffered by Chamorro villagers on the Pacific island of Guam. Many Chamorros with the disease suffer dementia, and in some villages one-quarter of the adults perished from the disease. Like Alzheimer's, the causal factors of Guamanian amyotrophic latera...
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Sensitive silver methods were employed for the examination of extracellular amyloid and intraneuronal neurofibrillary changes in the striatum of Alzheimer's disease patients. Numerous amyloid deposits were present in the striatum whereas neuritic (senile) plaques were only rarely encountered. Many large and a few medium-sized nerve cells had neurofibrillary tangles within their somata and accor...
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Cyclin-dependent kinase 5 (Cdk5) and its regulatory subunit p35 are integral players in the proper development of the mammalian central nervous system. Proteolytic cleavage of p35 generates p25, leading to aberrant Cdk5 activation. The accumulation of p25 is implicated in several neurodegenerative diseases. In primary neurons, p25 causes apoptosis and tau hyperphosphorylation. Current mouse mod...
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In Alzheimer disease, paired helical filaments accumulate in the neuron, and amyloid fibers are found in the extracellular space in the neuropil and brain vessels. Amyloid and paired helical filaments are morphologically distinct. Although messenger RNA that encodes the amyloid has also been shown in several tissues, including brain, the intracellular expression of the protein has not been obse...
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s: Burggren AC, Martin-Harris L, Suthana NS, Donix M, Ekstrom A, Jones M, Renner B, Kepe V, S-C Huang, Barrio JR, Ercoli LM, Miller KJ, Siddarth P, Small GW, Bookheimer SY. Correlation of cortical thickness within the medial temporal lobe to PET measures of brain amyloid and tau. Human Brain Mapping Conference June 2009.
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society B: Biological Sciences
سال: 2016
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.2015.2397